The Trypanosomatics Laboratory

Working on data integration to discover new drugs and diagnostics for human pathogens.

About

Our laboratory is interested in the study of human pathogens, particularly trypanosomes and also others that cause so-called Neglected Tropical Diseases.

We develop computational tools and produce (and re-use) large data sets to formulate and guide our research hypotheses in the quest for new drugs and diagnostics. Smart and intensive data integration, data mining, and high-throughput assays and experiments are at the core of our research activities.

In particular, we have a special interest in the study of trypanosomes such as Trypanosoma cruzi (causative of Chagas disease).

Wellcome to our electronic home in the web. Feel free to browse and poke around.

TDR Targets 6

Chemogenomics database: drug discovery for neglected diseases

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APRANK

A tool for genome-wide antigenicity predictions

Publication

ChagasTope

An Atlas of Chagas Disease Antigens and Epitopes

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Recent Posts

Beca ANPCyT 2022

Búsqueda de candidata/o a Beca Doctoral

Orientada a graduados en biotecnología, biología, bioquímica, o relacionadas.

Estamos buscando …

Last updated on Feb 25, 2022 2 min read

Alanine Scan for known Chagas antigens, November 2019 update

Chagas Disease is a major health problem for which no vaccine for public health interventions are yet available. Diagnosis is essential …
Last updated on Nov 11, 2019 8 min read

Serodiscordance and borderline serology, November 2019 update

Diagnosis of chronic Chagas Disease is currently based on serological techniques. Although available diagnostic tests give satisfactory …
Last updated on Nov 11, 2019 9 min read

Featured Publications

Highlights from our digital library

October 2019 Nucleic Acids Res, 48 (in production), https://doi.org/10.1093/nar/gkz999 Databases, Drug Discovery

TDR Targets 6: Driving drug discovery for human pathogens through intensive chemogenomic data integration

TDR Targets, a chemogenomics resource for Neglected Diseases

Project Project DOI TDR Targets Database
July 2015 Mol. Cell Proteomics, (14), 7, pp. 1871–84, https://doi.org/10.1074/mcp.M114.045906

Towards High-throughput Immunomics for Infectious Diseases: Use of Next-generation Peptide Microarrays for Rapid Discovery and Mapping of Antigenic Determinants

Setting the stage for high-throughput immunomics in Chagas Disease

PDF Dataset Project DOI

Recent & Upcoming Talks

Find us at these events and meetings

Development of a Chagas Disease Antigen and Epitope Atlas using massively parallel serological assays

How we used peptide arrays to discover new antigens and epitopes and map the presence of antibodies in patients
Aug 25, 2022 1:00 PM — Oct 25, 2022 2:30 PM Denmark & Virtual (Online)
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2022 SAP A drug-target prioritization strategy using the TDR Targets database leads to novel trypanocidal compounds with known active functional groups

Only got two mins? The drug repurposing approach to drug discovery for neglected diseases has shown to be effective to find potential …
Mar 17, 2022 6:15 PM — 9:00 PM Centro de Exposiciones Emilio Civit, Mendoza, Argentina
Project Project

2022 SAP Chagas Antigen Epitope Atlas

Mar 17, 2022 6:15 PM — 9:00 PM Centro de Exposiciones Emilio Civit, Mendoza, Argentina
Project

The serological antibody repertoire in Chagas Disease

Towards a comprehensive description of the specificities of individual antibody repertoires in Chagas Disease
Nov 16, 2019 5:00 PM — 7:00 PM Hotel 13 de Julio, Mar del Plata, Buenos Aires
Project

From yeast to tryps: repurposing strategies through conserved druggable modules

Computational repositioning of bioactive compounds from large chemogenomic screens: identification of conserved druggable modules …
Nov 14, 2019 4:30 PM — 6:30 PM Hotel 13 de Julio, Mar del Plata, Buenos Aires
Project Project
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Projects

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All Genetic Diversity Immunomics Drug Discovery

Diagnostics

Development of new diagnostic tools for infectious diseases
Project

High-throughput screening of trypanocidal agents

Identification and repurposing of bioactive compounds for Chagas disease: combining chemogenomics with high-throughput phenotypic …
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tdrtargets

Data integration for target prioritization and drug discovery or repurposing
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Genetic Diversity

A map of genetic variation for Trypanosoma cruzi and its use on strain typing applications
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Chemogenomics

Data integration for target prioritization and drug discovery or repurposing
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Congenital Chagas disease diagnosis

Antigens discovery for congenital Chagas disease, mapping and validation of epitopes for newborns serological diagnosis kit.
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Immunomics of Infectious Diseases

High-throuput screening and data integration for diagnostics tool development
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Yeast-to-Tryp Drug Repurposing

Exploiting conserved druggable modules between yeasts and trypanosomes for drug repurposing
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Recent Publications by lab members

From pre-prints to final publications, it’s all here

Quickly discover relevant content by filtering publications.

Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery

n this review, we discuss how genomics is being used for drug discovery in trypanosomatids.
Project DOI

APRANK: computational prioritization of antigenic proteins and peptides from complete pathogen proteomes

APRANK takes a pathogen proteome as input, and provides a ranked list of the best candidate antigens and epitopes.
Project DOI Code Data and Models Predictions

APRANK: computational prioritization of antigenic proteins and peptides from complete pathogen proteomes

APRANK can take a complete pathogen proteome as input, and provide a ranked list of the best candidate antigens…
PDF Code Dataset Project DOI

Screening and Identification of Metacaspase Inhibitors: Evaluation of Inhibition Mechanism and Trypanocidal Activity

A common strategy to identify new antiparasitic agents is the targeting of proteases, due to their essential contributions to parasite …
Project DOI

Target-based screening of the Chagas box: setting up enzymatic assays to discover specific inhibitors across bioactive compounds.

Chagas disease is a neglected tropical illness caused by the protozoan parasite Trypanosoma cruzi. The disease is endemic in Latin …
Project DOI
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Popular Topics

Built from tags in projects and publications

agencia antigenicity antigens biomarkers Chagas Disease chemogenomics congenital chagas diagnostics drug-discovery drug-repositioning epitopes genetic diversity genomics GSK-Chemboxes HTS immunomics MASP multilayer-networks neglected diseases networks pepchips peptides predictors proteins review SNPs strain typing tcruzi TcSNP TDR Targets

This is Us

The people behind the tryps

Investigators

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Fernán Agüero

Principal Investigator, Assistant Professor

Diagnostics, Drug Discovery, Bioinformatics, Genomics, Neglected Diseases, Trypanosomes

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Emir Salas Sarduy

Associate Investigator

Chemogenomics, Biochemistry, High-Throughput Screenings

Grad Students

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Armando E. Fernandez

PhD Student

Biochemistry of Proteins, Molecular Biology, Chagas Diseases, Recombinant Proteins

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Leonel Bracco

PhD Student

Diagnostics, Bioinformatics, Neglected Diseases, Congenital Chagas, Trypanosomes

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Mercedes Didier Garnham

PhD Student

Chemogenomics, Neglected Diseases, Drug Discovery

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Ramiro Quinteros

PhD Student

Bioinformatics, Chagas Disease, Data Analysis

Alumni

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Arianna Zuccolo Niño

Undergrad Student (BSc Thesis)

Biochemistry of Proteins, Molecular Biology, Chagas Diseases, Recombinant Proteins

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Florencia Bongiorni

Undergrad Student (BSc Thesis)

Biochemistry of Proteins, Molecular Biology, Chagas Diseases, Recombinant Proteins

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Franco Agüero

Undergrad Student (BSc Thesis)

Biochemistry of Proteins, Molecular Biology, Chagas Diseases, Recombinant Proteins

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Luz Sommariva

Undergrad Student (BSc Thesis)

Bioinformatics, Drug Discovery, Neglected diseases, Computer Science

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Quimey

Undergrad Student (BSc Thesis)

Biochemistry of Proteins, Molecular Biology, Chagas Diseases, Recombinant Proteins

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Sebastián Jinich

Undergrad Student (BSc Thesis)

Bioinformatics, Drug Discovery, Neglected diseases, Computer Science

Past Lab Members

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Alejandro A Ackermann

Former Lab Member (2005 – 2012)

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Alejandro Ricci

Former Lab Member (2016 – 2023)

Chagas Disease, Bioinformatics, Neural Networks

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Leonardo G Panunzi

Former Lab Member (2007 – 2014)

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Lionel Urán Landaburu

Former Lab Member (2016 – 2023)

Chemogenomics, Neglected diseases, Drug Discovery

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María Paula Magariños

Former Lab Member (2009 – 2014)

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Raúl O Cosentino

Former Lab Member (2007 – 2014)

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Santiago J Carmona

Former Lab Member (2007 – 2015)

Administration

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Trypanosomatics

A Trypanosome in the Shell

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