Immunomics of Infectious Diseases
Colorized image of a high-density peptide microarray
Unraveling the antibody diversity in Chagas Disease using antigen microarrays.
During an infection, the immune system produces antibodies against pathogens. With time, the immune repertoires of infected individuals become specific to the history of infections and thus represent a rich source of diagnostic markers. We are using high-density peptide arrays to examine the human antibody repertoires developed by Chagas Disease patients. The aim is to uncover the diversity of recognized antigens and build an atlas of antigens and epitopes for Chagas Disease.
Alejandro Ricci
Former Lab Member (2016 – 2023)
PhD Fellow. Processing big data to draw biological conclusions.
Santiago J Carmona
Former Lab Member (2007 – 2015)
Present address: Ludwig Center for Cancer Research, University of Lausanne
Fernán Agüero
Principal Investigator, Assistant Professor
Using and generating data to guide discovery of new drugs and diagnostics.
Posts
Beca ANPCyT 2022
Búsqueda de candidata/o a Beca Doctoral
Orientada a graduados en biotecnología, biología, bioquímica, o relacionadas.
Estamos buscando …
Alanine Scan for known Chagas antigens, November 2019 update
Chagas Disease is a major health problem for which no vaccine for public health interventions are yet available. Diagnosis is essential …
Serodiscordance and borderline serology, November 2019 update
Diagnosis of chronic Chagas Disease is currently based on serological techniques. Although available diagnostic tests give satisfactory …
Publications
APRANK: computational prioritization of antigenic proteins and peptides from complete pathogen proteomes
APRANK takes a pathogen proteome as input, and provides a ranked list of the best candidate antigens and epitopes.
APRANK: computational prioritization of antigenic proteins and peptides from complete pathogen proteomes
APRANK can take a complete pathogen proteome as input, and provide a ranked list of the best candidate antigens…
Next-generation ELISA diagnostic assay for Chagas Disease based on the combination of short peptidic epitopes
Chagas disease, caused by the parasite Trypanosoma cruzi, is a life-long and debilitating illness of major significance throughout …
Towards High-throughput Immunomics for Infectious Diseases: Use of Next-generation Peptide Microarrays for Rapid Discovery and Mapping of Antigenic Determinants
Setting the stage for high-throughput immunomics in Chagas Disease
TcTASV: a novel protein family in trypanosoma cruzi identified from a subtractive trypomastigote cDNA library
Discovery of a new family of differentially expressed genes in T. cruzi.
Talks
Antibody dynamics against specific T.cruzi antigens in patients undergoing chemotherapeutic treatments
Abstract Currently available first-line antiparasitic treatments against Chagas disease can produce adverse side effects and are not …
Development of a Chagas Disease Antigen and Epitope Atlas using massively parallel serological assays
How we used peptide arrays to discover new antigens and epitopes and map the presence of antibodies in patients
The serological antibody repertoire in Chagas Disease
Towards a comprehensive description of the specificities of individual antibody repertoires in Chagas Disease
Discovery and fine epitope mapping of novel serology-based markers for diagnosis of Congenital Chagas Disease using high-density peptide chips
How we use this technology to discover new antigens and epitopes in matched mother-newborn samples
