Publications

Lionel Urán Landaburu, Mercedes Didier Garnham, Fernán Agüero (2023). Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery. Biochem Soc Trans.

Alejandro Ricci, Mauricio Brunner, Diego Ramoa, Santiago J Carmona, Morten Nielsen, Fernán Agüero (2021). APRANK: computational prioritization of antigenic proteins and peptides from complete pathogen proteomes. Front Immunol.

Project DOI Code Data and Models Predictions

Alejandro Ricci, Mauricio Brunner, Diego Ramoa, Santiago J Carmona, Morten Nielsen, Fernán Agüero (2021). APRANK: computational prioritization of antigenic proteins and peptides from complete pathogen proteomes. 2021.04.27.441630.

PDF Code Dataset Project DOI

Brian Perez, Leon Bouvier, Juan J Cazzulo, Fernán Agüero, Emir Salas Sarduy, Vanina E Alvarez (2021). Screening and Identification of Metacaspase Inhibitors: Evaluation of Inhibition Mechanism and Trypanocidal Activity. Antimicrob Agents Chemoter 65(3): e01330-20.

Emir Salas Sarduy, Gabriela T Niemirowicz, Juan J Cazzulo, Vanina E Alvarez (2019). Target-based screening of the Chagas box: setting up enzymatic assays to discover specific inhibitors across bioactive compounds.. Curr Med Chem 26 (36).

Lionel Urán Landaburu, Ariel J Berenstein, Santiago Videla, Parag Maru, Dhanasekaran Shanmugam, Ariel Chernomoretz, Fernán Agüero (2019). TDR Targets 6: Driving drug discovery for human pathogens through intensive chemogenomic data integration. Nucleic Acids Res, 48 (in production), https://doi.org/10.1093/nar/gkz999.

Project Project DOI TDR Targets Database

Emir Salas Sarduy, Lionel Urán Landaburu, Adriana K Carmona, Juan J Cazzulo, Fernán Agüero, Vanina E Alvarez, Gabriela T Niemirowicz (2019). Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes. PLOS Negl Trop Dis, 13 (7), e0007560.

Maite Lobo, Virginia Balouz, Luciano Melli, Gianina Carlevaro, María E Cortina, María de los Milagros Cámara, Gaspar E Cánepa, Santiago J Carmona, Jaime Altcheh, Oscar Campetella, Andrés E Ciocchini, Fernán Agüero, Juan Mucci, Carlos A Buscaglia (2019). Molecular and antigenic characterization of Trypanosoma cruzi TolT proteins. PLOS Negl Trop Dis, (13), 3, pp. e0007245, https://doi.org/10.1371/journal.pntd.0007245.

Leandro G Roser, Fernán Agüero, Daniel O Sánchez (2018). FastqCleaner: an Interactive Bioconductor application for quality-control, filtering and trimming of FASTQ files. BMC Bioinformatics 20: 361.

Preprint PDF Code DOI

Juan Mucci, Santiago J Carmona, Romina Volcovich, Jaime Altcheh, Estefania Bracamonte, Jorge D Marco, Morten Nielsen, Carlos A Buscaglia, Fernán Agüero (2017). Next-generation ELISA diagnostic assay for Chagas Disease based on the combination of short peptidic epitopes. PLOS Negl Trop Dis, (11), 10, pp. e0005972, https://doi.org/10.1371/journal.pntd.0005972.

Ignacio M Durante, Pablo E La Spina, Santiago J Carmona, Fernán Agüero, Carlos A Buscaglia (2017). High-resolution profiling of linear B-cell epitopes from mucin-associated surface proteins (MASPs) of Trypanosoma cruzi during human infections.. PLOS Negl Trop Dis, (11), 9, pp. e0005986, https://doi.org/10.1371/journal.pntd.0005986.

Emir Salas Sarduy, Lionel Urán Landaburu, Joel Karpiak, Kevin P Madauss, Juan J Cazzulo, Fernán Agüero, Vanina E Alvarez (2017). Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes. Sci Rep, (7), 1, pp. 12073, https://doi.org/10.1038/s41598-017-12170-4.

Project Project DOI

Virginia Balouz, Fernán Agüero, Carlos A Buscaglia (2017). Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps. Adv Parasitol, (97), pp. 1–45, https://doi.org/10.1016/bs.apar.2016.10.001.

Ariel J Berenstein, María Paula Magariños, Ariel Chernomoretz, Fernán Agüero (2016). A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases. PLOS Negl Trop Dis, (10), 1, pp. e0004300, https://doi.org/10.1371/journal.pntd.0004300.

Project Project DOI

Carlos A Buscaglia, Jessica C Kissinger, Fernán Agüero (2015). Neglected Tropical Diseases in the Post-Genomic Era. Trends Genet, (31), 10, pp. 539–555, https://doi.org/10.1016/j.tig.2015.06.002.

Santiago J Carmona, Morten Nielsen, Claus Schafer-Nielsen, Juan Mucci, Jaime Altcheh, Virginia Balouz, Valeria Tekiel, Alberto C Frasch, Oscar Campetella, Carlos A Buscaglia, Fernán Agüero (2015). Towards High-throughput Immunomics for Infectious Diseases: Use of Next-generation Peptide Microarrays for Rapid Discovery and Mapping of Antigenic Determinants. Mol. Cell Proteomics, (14), 7, pp. 1871–84, https://doi.org/10.1074/mcp.M114.045906.

PDF Dataset Project DOI

Virginia Balouz, María de los Milagros Cámara, Gaspar E Cánepa, Santiago J Carmona, Romina Volcovich, Nicolás Gonzalez, Jaime Altcheh, Fernán Agüero, Carlos A Buscaglia (2015). Mapping antigenic motifs in the trypomastigote small surface antigen from Trypanosoma cruzi. Clin. Vaccine Immunol., (22), 3, pp. 304–12, https://doi.org/10.1128/CVI.00684-14.

Leonardo G Panunzi, Fernán Agüero (2014). A genome-wide analysis of genetic diversity in Trypanosoma cruzi intergenic regions. PLOS Negl Trop Dis, (8), 5, pp. e2839, https://doi.org/10.1371/journal.pntd.0002839.

Raúl O Cosentino, Fernán Agüero (2014). Genetic profiling of the isoprenoid and sterol biosynthesis pathway genes of Trypanosoma cruzi. PLOS One, (9), 5, pp. e96762, https://doi.org/10.1371/journal.pone.0096762.

María C Dalmasso, Santiago J Carmona, Sergio O Angel, Fernán Agüero (2014). Characterization of Toxoplasma gondii subtelomeric-like regions: identification of a long-range compositional bias that is also associated with gene-poor regions. BMC Genomics, (15), pp. 21, https://doi.org/10.1186/1471-2164-15-21.

Javier G De Gaudenzi, Santiago J Carmona, Fernán Agüero, Alberto C Frasch (2013). Genome-wide analysis of 3'-untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes. PeerJ, (1), pp. e118, https://doi.org/10.7717/peerj.118.

Raúl O Cosentino, Fernán Agüero (2012). A simple strain typing assay for Trypanosoma cruzi: discrimination of major evolutionary lineages from a single amplification product. PLOS Negl Trop Dis, (6), 7, pp. e1777, https://doi.org/10.1371/journal.pntd.0001777.

Dhanasekaran Shanmugam, Stuart A Ralph, Santiago J Carmona, Gregory J Crowther, David S Roos, Fernán Agüero (2012). Integrating and Mining Helminth Genomes to Discover and Prioritize Novel Therapeutic Targets. Chapter 3, pp. 43-59, In ‘Parasitic Helminths: Targets, Screens, Drugs and Vaccines’, Edited by Conor R Caffrey, Wiley, Weinheim, Germany, https://doi.org/10.1002/9783527652969.ch3.

PDF Project Project DOI

María Paula Magariños, Santiago J Carmona, Gregory J Crowther, Stuart A Ralph, David S Roos, Dhanasekaran Shanmugam, Wesley C Van Voorhis, Fernán Agüero (2012). TDR Targets: A Chemogenomics Resource for Neglected Diseases. Nucl Acids Res, (40), pp. D1118-27, https://doi.org/10.1093/nar/gkr1053.

Project Project DOI TDR Targets Database

Santiago J Carmona, Paula A Sartor, Maria S Leguizamon, Oscar E Campetella, Fernán Agüero (2012). Diagnostic peptide discovery: prioritization of pathogen diagnostic markers using multiple features. PLOS One, (7), 12, pp. e50748, https://doi.org/10.1371/journal.pone.0050748.

Alejandro A Ackermann, Leonardo G Panunzi, Raúl O Cosentino, Daniel O Sánchez, Fernán Agüero (2012). A genomic scale map of genetic diversity in Trypanosoma cruzi.. BMC Genomics, (13), pp. 736, https://doi.org/10.1186/1471-2164-13-736.

Project DOI TcSNP Database

Ivana Urban, Lucía B Santurio, Agustina Chidichimo, Hai Yu, Xi Chen, Juan Mucci, Fernán Agüero, Carlos A Buscaglia (2011). Molecular diversity of the Trypanosoma cruzi TcSMUG family of mucin genes and proteins. Biochem J, (438), 2, pp. 303-13, https://doi.org/10.1042/BJ20110683.

Elizabeth A García, María Ziliani, Fernán Agüero, Guillermo Bernabó, Daniel O Sánchez, Valeria Tekiel (2010). TcTASV: a novel protein family in trypanosoma cruzi identified from a subtractive trypomastigote cDNA library. PLOS Negl Trop Dis, (4), 10, pp. e841, http://doi.org/10.1371/journal.pntd.0000841.

Gregory J Crowther, Dhanasekaran Shanmugam, Santiago J Carmona, Maria A Doyle, Christiane Hertz-Fowler, Matthew Berriman, Solomon Nwaka, Stuart A Ralph, David S Roos, Wesley C Van Voorhis, Fernán Agüero (2010). Identification of attractive drug targets in neglected-disease pathogens using an in silico approach. PLOS Negl Trop Dis, (4), pp. e804, https://doi.org/10.1371/journal.pntd.0000804.

PDF Project Project DOI

Paula M Moolhuijzen, Ala E Lew-Tabor, Bartosz M Wlodek, Fernán Agüero, Diego J Comerci, Rodolfo A Ugalde, Daniel O Sánchez, Rudi Appels, Matthew M Bellgard (2009). Genomic analysis of Campylobacter fetus subspecies: identification of candidate virulence determinants and diagnostic assay targets. BMC Microbiol, (9), pp. 86, http://doi.org/10.1186/1471-2180-9-86.

Alejandro A Ackermann, Santiago J Carmona, Fernán Agüero (2009). TcSNP: a database of genetic variation in Trypanosoma cruzi. Nucleic Acids Res, (37), Database issue, pp. D544-9, http://doi.org/10.1093/nar/gkn874.

Project DOI TcSNP Database

Fernán Agüero, Bissan Al-Lazikani, Martin Aslett, Matthew Berriman, Frederick S Buckner, Robert K Campbell, Santiago J Carmona, Ian M Carruthers, Chan AW, Fen Chen, Gregory J Crowther, Maria A Doyle, Christiane Hertz-Fowler, Andrew L Hopkins, McAllister G, Solomon Nwaka, John P Overington, Arnab Pain, Gaia V Paolini, Ursula Pieper, Stuart A Ralph, Aaron Riechers, David S Roos, Andrej Sali, Dhanasekaran Shanmugam, Takashi Suzuki, Wesley C Van Voorhis, Christophe L Verlinde (2008). Genomic-scale prioritization of drug targets: the TDR Targets database. Nat Rev Drug Dis, (7), 11, pp. 900-7, http://doi.org/10.1038/nrd2684.

Project Project DOI TDR Targets Database