TcTASV: a novel protein family in trypanosoma cruzi identified from a subtractive trypomastigote cDNA library
Alignment of TcTASV members
Abstract
Differentially expressed genes are the hallmark of the specialized biology of each life cycle stage. The aim of this work was to identify genes expressed in the trypomastigote stage (a blood-circulating stage that invades new cells and spreads the infection in different organs of the mammalian host) that could be used to develop new vaccines or diagnostics. An initial screening of trypomastigote transcripts was performed by sequencing of an epimastigote-subtracted trypomastigote cDNA library. Besides identifying a large proportion of differentially expressed mRNAs, we discovered a novel protein family, which we denominated TcTASV.
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Publication
PLOS Neglected Tropical Diseases, (4), 10, pp. e841, http://doi.org/10.1371/journal.pntd.0000841
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Fernán Agüero
Principal Investigator, Assistant Professor
Using and generating data to guide discovery of new drugs and diagnostics.