antigens

Development of a Chagas Disease Antigen and Epitope Atlas using massively parallel serological assays

How we used peptide arrays to discover new antigens and epitopes and map the presence of antibodies in patients

2022 SAP Chagas Antigen Epitope Atlas

Diagnostics

Development of new diagnostic tools for infectious diseases

APRANK: computational prioritization of antigenic proteins and peptides from complete pathogen proteomes

APRANK takes a pathogen proteome as input, and provides a ranked list of the _best_ candidate antigens and epitopes.

APRANK: computational prioritization of antigenic proteins and peptides from complete pathogen proteomes

APRANK can take a complete pathogen proteome as input, and provide a ranked list of the _best_ candidate antigens...

The serological antibody repertoire in Chagas Disease

Towards a comprehensive description of the specificities of individual antibody repertoires in Chagas Disease

Molecular and antigenic characterization of Trypanosoma cruzi TolT proteins

Discovery and fine epitope mapping of novel serology-based markers for diagnosis of Congenital Chagas Disease using high-density peptide chips

How we use this technology to discover new antigens and epitopes in matched mother-newborn samples

Next-generation ELISA diagnostic assay for Chagas Disease based on the combination of short peptidic epitopes

Chagas disease, caused by the parasite Trypanosoma cruzi, is a life-long and debilitating illness of major significance throughout Latin America, and an emergent threat to global public health. Diagnostic tests are key tools to support disease …