n this review, we discuss how genomics is being used for drug discovery in trypanosomatids.
Only got two mins? The drug repurposing approach to drug discovery for neglected diseases has shown to be effective to find potential therapeutic agents. For Chagas disease, in particular, with some of these agents even making it to clinical trials. We have shown that a programmatic approach for drug repurposing, using intensive chemogenic data integration strategies, can recall known bioactive compounds and druggable targets for a selected pathogen species, and can also recommend novel drug-target pairs for further experimental validation (Berenstein et al, 2016).
Computational repositioning of bioactive compounds from large chemogenomic screens: identification of conserved druggable modules between yeasts and trypanosomes
Mind the gap: Bridging the knowledge rift between model organisms and pathogens causing neglected diseases
TDR Targets, a chemogenomics resource for Neglected Diseases
Identification and repurposing of bioactive compounds for Chagas disease: combining chemogenomics with high-throughput phenotypic screening
Data integration for target prioritization and drug discovery or repurposing
A recap on updates & updagrades for TDR Targets chemogenomics resource to aid on drug discovery, repurposing and develeopment for neglected diseases
Data integration for target prioritization and drug discovery or repurposing
Exploiting conserved druggable modules between yeasts and trypanosomes for drug repurposing