Only got two mins? The drug repurposing approach to drug discovery for neglected diseases has shown to be effective to find potential therapeutic agents. For Chagas disease, in particular, with some of these agents even making it to clinical trials. We have shown that a programmatic approach for drug repurposing, using intensive chemogenic data integration strategies, can recall known bioactive compounds and druggable targets for a selected pathogen species, and can also recommend novel drug-target pairs for further experimental validation (Berenstein et al, 2016).
Computational repositioning of bioactive compounds from large chemogenomic screens: identification of conserved druggable modules between yeasts and trypanosomes
Mind the gap: Bridging the knowledge rift between model organisms and pathogens causing neglected diseases
TDR Targets, a chemogenomics resource for Neglected Diseases
Identification and repurposing of bioactive compounds for Chagas disease: combining chemogenomics with high-throughput phenotypic screening
Data integration for target prioritization and drug discovery or repurposing
Data integration for target prioritization and drug discovery or repurposing
Exploiting conserved druggable modules between yeasts and trypanosomes for drug repurposing
Neglected tropical diseases are human infectious diseases that are often associated with poverty. Historically, lack of interest from the pharmaceutical industry resulted in the lack of good drugs to combat the majority of the pathogens that cause …